A medical transport plane carrying a pediatric patient, her mother, and four crew members crashed into a Philadelphia neighborhood Friday night, erupting into a fireball and engulfing nearby homes and cars in flames.

Philadelphia officials say the six people onboard the plane have died.

The crash happened along Cottman Avenue near Bustleton Avenue and the Roosevelt Mall shortly after 6 p.m.

Philadelphia Mayor Cherelle Parker, speaking at the scene, said that officials had yet to confirm the number of fatalities. Several surrounding homes and vehicles were also impacted by the crash Parker confirmed.

“This is a tragedy in our city – people have lost their lives and many injured in this horrific crash and the damage is significant,” said Mayor Cherelle L. Parker. “Our prayers are with the families, friends, neighbors and all of those impacted by the tragic crash.  We are unified in our approach – a One Philly philosophy with all hands-on deck. I am so grateful for the rapid response by our Philadelphia Police and Fire Departments, our Office of Emergency Management and Philadelphia Gas Works with federal, state, and local first responders who swarmed the scene in collaboration with all first responders on the ground.”