Ukraine has fired US-made ATACMS missiles into Russia’s Bryansk region, Russia’s Defense Ministry said, in a major escalation on the 1,000th day of war.

The attack comes just two days after the Biden administration gave Kyiv the green light to use the longer-range American weapons against targets inside Russia.

Kyiv did not immediately respond to the report. The attack marks the first time Ukraine has used the longer-range American weapons to strike targets deep inside Russia, and show that Kyiv has wasted little time in making use of its newly-granted powers.

Ukraine has fired US-made ATACMS missiles into Russia’s Bryansk region, Russia’s Defense Ministry said, in a major escalation on the 1,000th day of war.

The attack comes just two days after the Biden administration gave Kyiv the green light to use the longer-range American weapons against targets inside Russia.