The NYPD’s highest-ranking uniformed officer abruptly resigned late Friday night after The Post uncovered explosive allegations that he demanded sexual favors from a subordinate in exchange for massive amounts of overtime.

Chief of Department Jeffrey Maddrey stepped down soon after The Post contacted the NYPD about Lt. Quathisha Epps’ claims in an exclusive interview that he routinely preyed upon her, asking for sex in NYPD headquarters.

“He wanted to have anal sex, vaginal sex, oral sex,” Epps said. “He was always asking me to kiss his penis.”

Maddrey,a close friend of Mayor Adams, will be replaced on an interim basis by Chief of Patrol John Chell, the NYPD said.

“Police Commissioner Jessica S. Tisch accepted the resignation of Chief of Department Jeffrey Maddrey Friday night, effective immediately,” said a department spokesperson. “The NYPD takes all allegations of sexual misconduct seriously, and will thoroughly investigate this matter.”