A key community board rejected a bid to build a glittering $12 billion casino complex in Manhattan’s Hudson Yards — a potential death blow for the project.

Community Board 4 — which represents the Hudson Yards neighborhood — voted unanimously Monday night against approving a zoning change to allow the project by Related Companies and Wynn to proceed.

Under the city’s Uniformed Land Use Procedure, the local board has a right to weigh in on the zoning change, though the vote is advisory.

Ultimately, the City Council must sign off along with city planners in Mayor Eric Adams’ administration.